General Clinical Chemistry Analyzers and Accessories
Abcam CCG 1423, Rho pathway-mediated signaling inhibitor, 5MG
MW 454.7 Da, Purity >98%. Specific inhibitor of Rho pathway-mediated signaling and activation of serum response factor (SRF) transcription. Displays activity in several in vitro cancer cell functional assays. Potently (<1 mumol/L) inhibits lysophosphatidic acid-induced DNA synthesis in PC-3 prostate cancer cells, inhibits growth of RhoC-overexpressing melanoma lines at nanomolar concentrations. Selectively stimulates apoptosis of the metastasis-prone, RhoC-overexpressing melanoma cell lines. Acts at or downstream of MLK1 and upstream of SRF. Blocks MLK1 nuclear localization.
The product is subject to the following: Abcam Restricted Use Statement
Abcam G10, STING signaling activator, 5MG
MW 430.9 Da, Purity >98%. G10 is an indirect activator or stimulator of interferon genes (STING) signaling. It induces transcription of genes dependent on IRF3 and IFN, which are activated by STING, but has no effect on non-STING activated NF-κB-dependent transcription of IL-8, IL-1β, or MIP-1α in human fibroblasts. However, G10 does increase expression of NF-κB-dependent genes in human peripheral blood mononuclear cells (PBMCs) and human umbilical microvascular endothelial cells (HUMECs). In vitro, it prevents replication of the chikungunya and Venezuelan equine encephalitis alphaviruses (IC₉₀s = 8.01 and 24.57 μM, respectively). G10 (100 μM) increases phosphorylation of IRF3, which is lost in cells lacking STING.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Narciclasine, Rho/LIM kinase/cofilin signaling pathway activator, 1MG
MW 307.25 Da, Purity >98%. Plant growth regulator originally isolated from Narcissus bulbs. Exhibits antiproliferative and pro-apoptotic effects in carcinoma cells and displays cytotoxic activity against a panel of 60 cancer cell lines (mean IC₅₀ = 47 nM). Activity decreases rate of cell division and increases mitosis duration in vitro. Also modulates the Rho/ROCK/LIM kinase/cofilin pathway; stimulates RhoA activation and induces actin polymerization.
The product is subject to the following: Abcam Restricted Use Statement
Abcam CK869, Actin-related protein 2/3 (Arp2/3) comple x inhibitor, 25MG
MW 394.3 Da, Purity >98%. Inhibitor of human and bovine actin-related protein 2/3 (Arp2/3) complex. Inhibits actin polymerization with bovine Arp2/3 complex (IC₅₀ = 11 μM) and inhibits the formation of actin filament comet tails by Listeriamonocytogenes in infected SKOV3 cells (IC₅₀ = 7 μM) . Does not inhibit budding or fission yeast Arp2/3 complexes.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Monochlorobimane, 5MG
MW 226.66 Da, Purity >=98%. Monochlorobimane is a cell-permeant probe for quantifying glutathione levels in cells. It is essentially nonfluorescent until it reacts with a thiol group. It readily reacts with several low molecular weight thiols, including cysteine, glutathione, N-acetylcysteine, mercaptopurine, peptides and plasma thiols. The glutathione conjugate of monochlorobimane has an excitation/emission maxima ~394/490 nm.
The product is subject to the following: Abcam Restricted Use Statement
Abcam CCT-251921, 1MG
MW 410.9 Da, Purity >=98%. CCT-251921 is a potent, selective, small-molecule modulator of the mediator complex-associated kinases CDK8 and CDK19 (IC₅₀, CDK8 = 2.3 nM; CDK19 = 2.6 nM).
The product is subject to the following: Abcam Restricted Use Statement
Abcam BMS-986142, 5MG
MW 572.6 Da, Purity >=98%. BMS-986142 is a potent, selective, and reversible BTK (Bruton's tyrosine kinase) inhibitor (BTK IC₅₀ = 0.5nM; human WB IC₅₀ = 90 nM). BMS-986142 displays robust efficacy in murine models of rheumatoid arthritis (RA), including collagen-induced arthritis (CIA) and collagen antibody-induced arthritis (CAIA).
The product is subject to the following: Abcam Restricted Use Statement
Abcam SRT-3025 hydrochloride, 25MG
MW 606.2 Da, Purity >=98%. SRT-3025 is a potent and selective Sirt1 activator. It inhibits RANKL-induced osteoclast differentiation, fusion and resorptive capacity without affecting osteoclast survival. SRT-3025 inhibits RANKL-induced osteoclastogenesis in bone marrow-derived macrophages (BMMs) by activating AMPK and deacetylating RelA/p65 lysine 310, critical for activation of the NF-κB signaling pathway.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Umifenovir, 5MG
MW 477.4 Da, Purity >=95%. An indole derivative with broad-spectrum antiviral activity. It inhibits virus-mediated fusion with target membrane and blocks virus entry into target cells. It shows antiviral activity against many enveloped or non-enveloped RNA or DNA viruses with IC₅₀ values ranging from 0.41 to 16 uM. It (50 or 100 mg/kg/day) reduces mean pulmonary virus yields and the rate of mortality in mice infected with FLU-A (A/PR/8/34 H1N1). Molecular dynamics and structural analysis show that Umifenovir may target SARS-CoV-2 spike glycoprotein and may block its trimerization which will reduce cell adherence and virus entry.
The product is subject to the following: Abcam Restricted Use Statement
Abcam LGK974, 1MG
MW 396.4 Da, Purity >=98%. LGK-974 is a potent and specific inhibitor of Porcupine (porcn), a Wnt-specific acyltransferase (IC₅₀ = ~0.4 nM). GK974 potently inhibits Wnt signaling, has strong efficacy in rodent tumor models, and is well-tolerated. In addition, head and neck cancer cell lines with loss-of-function mutations in the Notch signaling pathway have a high response rate to LGK974.
The product is subject to the following: Abcam Restricted Use Statement
Abcam HDM-201 (Siremadlin), 5MG
MW 555.4 Da, Purity >=98%. Potent and highly specific MDM-2/p53 inhibitor. It binds to human MDM2 protein with a picomolar Ki value (0.21 nM). It activates p53 and induces robust p53-dependent cell cycle arrest and apoptosis in human p53 wild-type tumor cells.
The product is subject to the following: Abcam Restricted Use Statement
Abcam GL x -351322, 5MG
MW 431.5 Da, Purity >=98%. GLX-351322 is a potent NADPH oxidase-4 (NOX-4) inhibitor. Displays selectivity for NOX-4 over NOX-2. GLX-351322 inhibits hydrogen peroxide production from tetracycline inducible NOX4-overexpressing cells (IC₅₀ = 5 μM).
The product is subject to the following: Abcam Restricted Use Statement
Abcam Apremilast, 5MG
MW 460.5 Da, Purity >98%. Ppotent PDE4 (phosphodiesterase 4) inhibitor (IC₅₀ = 74 nM). It reduces TNF-α production in human synovial cells and significantly suppresses experimental arthritis.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Qstatin, 25MG
MW 293.2 Da, Purity >=98%. A potent, and selective Vibrio QS inhibitor which affects Vibrio harveyi LuxR homologues, the well-conserved master transcriptional regulators for QS in Vibrio species. QStatin binds tightly to a putative ligand-binding pocket in SmcR, the LuxR homologue in V. vulnificus, and changes the flexibility of the protein, thereby altering its transcription regulatory activity.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Furamidine dihydrochloride, 25MG
MW 304.3 Da, Purity >=98%. A potent, selective and cell-permeable protein arginine methyltransferase 1 (PRMT1) inhibitor (IC₅₀ = 9.4 μM). Displays selectivity over PRMT5, PRMT6 and CARM1 (IC₅₀ values are 166, 283 and >400 μM respectively). Inhibits cell proliferation in leukemia cell lines.
The product is subject to the following: Abcam Restricted Use Statement